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Featured by fast structural determination of proteins at near-physiological states and no need to grow crystals, Cryo-EM is playing increasingly important roles in drug discovery. Cryo-EM technology is well suited for targets that are challenging for traditional X-ray crystallography or NMR, such as protein complex, membrane proteins or PROTAC/molecular glue ternary complexes. Fast structure determination of targets at atomic resolution makes cryo-EM a very useful tool for structure-based drug discovery (SBDD).
Cryo-EM Single Particle Analysis is playing increasing roles in structure-based drug discovery (SBDD). The typical workflow includes sample negative staining, cryo grids preparation and optimization, and high resolution cryo-EM data collection & structural determination.
~100 cryo-EM structures delivered, highest resolution 2Å, median resolution 3Å;
All structures shown above have been desensitized to avoid any IP issues.
Lipid nanoparticles (LNPs) are designed to encapsulate siRNA, which represent a highly promising category of drug-delivery system. Cryo-EM can be used for characteriations of nanoparticle samples in their near-native states.
Examples
Microcrystal electron diffraction (MicroED) is a powerful technique for high resolution structure determination of small molecules. Microcrystals with a dimension of 100nm to 400nm is too small for routine X-ray crystallography yet good for MicroED. MicroED can determine the atomic resolution (usually better than 1 Å) structures of small molecules within a few days.
With its advantages in the field of structure-based drug discovery (SBDD), Viva Biotech provides a full range of preclinical innovative drug R&D services. The cryo-EM platform provides negative staining, cryo grid screening and optimization of frozen samples, high-resolution data collection and processing, model building and analysis services.
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